Anti-TMEM43 antibody [SRM13164] (STJ11107894)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal Transmembrane Protein 43 antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM13164 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB, 1:500-1:1000IHC-P, 1:50-1:200ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMEM43 |
| Gene ID | 79188 |
| Uniprot ID | TMM43_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
| Immunogen Sequence | Human |
Additional Info
| Function | May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10. Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination. |
| Protein Name | Transmembrane Protein 43Protein Luma |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneNucleus Inner MembraneMulti-Pass Membrane ProteinCell MembraneRetained In The Inner Nuclear Membrane Through Interaction With Emd And A- And B-LaminsThe N- And C-Termini Are Oriented Towards The NucleoplasmThe Majority Of The Hydrophilic Domain Resides In The Endoplasmic Reticulum Lumen |
| Alternative Antibody Names | Anti-Transmembrane Protein 43 antibodyAnti-Protein Luma antibodyAnti-TMEM43 antibodyAnti-UNQ2564 antibodyAnti-PRO6244 antibody |
Information sourced from Uniprot.org