Anti-TMEM30A antibody (110-190 aa) (STJ191662)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 110-190
General Information
| Short Description | Rabbit polyclonal anti-Cell cycle control protein 50A (110-190 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMEM30A |
| Gene ID | 55754 |
| Uniprot ID | CC50A_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 110-190 |
| Immunogen Region | 110-190 aa |
| Specificity | CC50A Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediates the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. |
| Protein Name | Cell Cycle Control Protein 50aP4-Atpase Flippase Complex Beta Subunit Tmem30aTransmembrane Protein 30a |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneGolgi ApparatusCytoplasmic VesicleSecretory Vesicle MembraneApical Cell Membrane |
| Alternative Antibody Names | Anti-Cell Cycle Control Protein 50a antibodyAnti-P4-Atpase Flippase Complex Beta Subunit Tmem30a antibodyAnti-Transmembrane Protein 30a antibodyAnti-TMEM30A antibodyAnti-C6orf67 antibodyAnti-CDC50A antibody |
Information sourced from Uniprot.org