| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Transmembrane protein 131-like (321-371 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TMEM131L |
| Gene ID: | 23240 |
| Uniprot ID: | T131L_HUMAN |
| Immunogen Region: | 321-371 aa |
| Specificity: | This antibody detects endogenous levels of T131L at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human T131L at the amino acid range 321-371 |
| Function | Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. |
| Protein Name | Transmembrane Protein 131-Like |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmDuring Intrathymic DevelopmentResides In Punctate Cytoplasmic Structures In Dn1 And Dn2 CellsIn Dn3 CellsFound In Large Crescent-Shaped Membrane StructuresWhich Preferentially Localize In Cell-To-Cell Contact ZonesIsoform 1: Endoplasmic ReticulumTransmembrane Localization Is Essential For Wnt Signaling InhibitionIsoform 5: CytoplasmScattered Throughout The Cytoplasm In Small-Sized Punctate Structures |
| Alternative Antibody Names | Anti-Transmembrane Protein 131-Like antibodyAnti-TMEM131L antibodyAnti-KIAA0922 antibody |
Information sourced from Uniprot.org