• Western blot analysis of lysates from HCT116 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-TMEM131L antibody (321-371 aa) (STJ195432)

SKU:
STJ195432

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transmembrane protein 131-like (321-371 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TMEM131L
Gene ID: 23240
Uniprot ID: T131L_HUMAN
Immunogen Region: 321-371 aa
Specificity: This antibody detects endogenous levels of T131L at Human/Mouse
Immunogen: Synthesized peptide derived from the human T131L at the amino acid range 321-371
Function Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
Protein Name Transmembrane Protein 131-Like
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
During Intrathymic Development
Resides In Punctate Cytoplasmic Structures In Dn1 And Dn2 Cells
In Dn3 Cells
Found In Large Crescent-Shaped Membrane Structures
Which Preferentially Localize In Cell-To-Cell Contact Zones
Isoform 1: Endoplasmic Reticulum
Transmembrane Localization Is Essential For Wnt Signaling Inhibition
Isoform 5: Cytoplasm
Scattered Throughout The Cytoplasm In Small-Sized Punctate Structures
Alternative Antibody Names Anti-Transmembrane Protein 131-Like antibody
Anti-TMEM131L antibody
Anti-KIAA0922 antibody

Information sourced from Uniprot.org

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