| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | TMEM106A |
| Gene ID: | 113277 |
| Uniprot ID: | T106A_HUMAN |
| Immunogen Region: | 1-93 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-93 of human TMEM106A (NP_659478.1). |
| Immunogen Sequence: | MGKTFSQLGSWREDENKSIL SSKPAIGSKAVNYSSTGSSK SFCSCVPCEGTADASFVTCP TCQGSGKIPQELEKQLVALI PYGDQRLKPKHTK |
| Tissue Specificity | Expressed in renal cells (at protein level). Expressed in epithelial cells. |
| Function | Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide. May play a role in inhibition of proliferation and migration. |
| Protein Name | Transmembrane Protein 106a |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Transmembrane Protein 106a antibody Anti-TMEM106A antibody |
Information sourced from Uniprot.org