Anti-TMED2 antibody (60-170) (STJ119684)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TMED2 (60-170) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMED2 |
| Gene ID | 10959 |
| Uniprot ID | TMED2_HUMAN |
| Immunogen Region | 60-170 |
| Immunogen Sequence | EITGPDNKGIYKGDRESSGK YTFAAHMDGTYKFCFSNRMS TMTPKIVMFTIDIGEAPKGQ DMETEAHQNKLEEMINELAV AMTAVKHEQEYMEVRERIHR AINDNTNSRVV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1). |
Additional Info
| Function | Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor.the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. |
| Protein Name | Transmembrane Emp24 Domain-Containing Protein 2Membrane Protein P24aP24P24 Family Protein Beta-1P24beta1 |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6807878Reactome: R-HSA-6811434 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneSingle-Pass Type I Membrane ProteinCytoplasmic VesicleCopi-Coated Vesicle MembraneGolgi ApparatusCis-Golgi Network MembraneGolgi Stack MembraneEndoplasmic Reticulum MembraneEndoplasmic Reticulum-Golgi Intermediate Compartment MembraneCycles Between Compartments Of The Early Secretatory Pathway |
| Alternative Antibody Names | Anti-Transmembrane Emp24 Domain-Containing Protein 2 antibodyAnti-Membrane Protein P24a antibodyAnti-P24 antibodyAnti-P24 Family Protein Beta-1 antibodyAnti-P24beta1 antibodyAnti-TMED2 antibodyAnti-RNP24 antibody |
Information sourced from Uniprot.org