| Function | Acts as a regulatory protein involved in the regulation of numerous cellular processes. Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally. Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER. Down-regulates the activity of transcription factors induced by zinc and cytokines. Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons. |
| Protein Name | Transmembrane Channel-Like Protein 6Epidermodysplasia Verruciformis Protein 1Protein Lak-4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneNucleus MembraneLocalizes To The ErGolgi And Nucleus Membranes In Keratinocytes |
| Alternative Antibody Names | Anti-Transmembrane Channel-Like Protein 6 antibodyAnti-Epidermodysplasia Verruciformis Protein 1 antibodyAnti-Protein Lak-4 antibodyAnti-TMC6 antibodyAnti-EVER1 antibodyAnti-EVIN1 antibody |
Information sourced from Uniprot.org
