| Short Description : | Rabbit polyclonal anti-TMC4 for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/WB |
| Host: | Rabbit |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested i other applications. |
| Formulation: | Lyophilised |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Tmc4 |
| Gene ID: | 353499 |
| Uniprot ID: | TMC4_MOUSE |
| Immunogen: | A synthetic peptide from mouse TMC4 conjugated to blue carrier protein was used as the antigen. |
| Specificity: | Specific for TMC4. |
| Function | Voltage-gated chloride channel involved in high-concentration salt taste sensation. Depolarization induced by high NaCl concentration may trigger the activation of TMC4-mediated chloride influx into taste bud cells, helping the return to resting potential. Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride. Involved in pH and temperature-dependent modulation of salty taste. |
| Protein Name | Voltage-Gated Chloride Channel Tmc4Transmembrane Channel-Like Protein 4 |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Gated Chloride Channel Tmc4 antibodyAnti-Transmembrane Channel-Like Protein 4 antibodyAnti-Tmc4 antibody |
Information sourced from Uniprot.org
