Anti-TMC2 antibody (705-755 aa) (STJ194283)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TMC2 at the amino acid range 705-755
General Information
| Short Description | Rabbit polyclonal anti-Transmembrane channel-like protein 2 (705-755 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMC2 |
| Gene ID | 117532 |
| Uniprot ID | TMC2_HUMAN |
| Immunogen | Synthesized peptide derived from the human TMC2 at the amino acid range 705-755 |
| Immunogen Region | 705-755 aa |
| Specificity | This antibody detects endogenous levels of TMC2 at Human/Mouse |
Additional Info
| Function | Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located. TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear. |
| Protein Name | Transmembrane Channel-Like Protein 2Transmembrane Cochlear-Expressed Protein 2 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Stereocilia Tips Of The Cochlear Hair Cells And Plasma Membranes Of Cuticular Plates |
| Alternative Antibody Names | Anti-Transmembrane Channel-Like Protein 2 antibodyAnti-Transmembrane Cochlear-Expressed Protein 2 antibodyAnti-TMC2 antibodyAnti-C20orf145 antibodyAnti-UNQ907 antibodyAnti-PRO1928 antibody |
Information sourced from Uniprot.org