• Immunohistochemistry of rat spleen with Anti-TLR3 primary antibody (STJ503277) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-TLR3 antibody (650-700) (STJ503277)

SKU:
STJ503277-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TLR3 (650-700) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.65-0.77 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:20, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TLR3
Gene ID: 7098
Uniprot ID: TLR3_HUMAN
Immunogen Region: 650-700
Immunogen: Synthetic peptide taken within amino acid region 650-700 on human TLR3 protein.
Tissue Specificity Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
Post Translational Modifications Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes. Ubiquitinated by TRIM3.leading to recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes. Ubiquitinated by ZNRF1 via 'Lys-63'-linked ubiquitin chains.leading to TLR3 lysosomal trafficking and degradation.
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Protein Name Toll-Like Receptor 3
Cd Antigen Cd283
Database Links Reactome: R-HSA-1679131
Reactome: R-HSA-168164
Reactome: R-HSA-168927
Reactome: R-HSA-1810476
Reactome: R-HSA-5602410
Reactome: R-HSA-5602415
Reactome: R-HSA-5602566
Reactome: R-HSA-5602571
Reactome: R-HSA-9013957
Reactome: R-HSA-9013973
Reactome: R-HSA-9014325
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Endosome Membrane
Early Endosome
Alternative Antibody Names Anti-Toll-Like Receptor 3 antibody
Anti-Cd Antigen Cd283 antibody
Anti-TLR3 antibody

Information sourced from Uniprot.org

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