| Tissue Specificity | Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. |
| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
| Protein Name | Serine/Threonine-Protein Kinase Tousled-Like 1Pku-BetaTousled-Like Kinase 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tousled-Like 1 antibodyAnti-Pku-Beta antibodyAnti-Tousled-Like Kinase 1 antibodyAnti-TLK1 antibodyAnti-KIAA0137 antibody |
Information sourced from Uniprot.org
