| Host: | Rabbit |
| Applications: | IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Serine/threonine-protein kinase tousled-like 1 (730-779 aa) is suitable for use in Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IF 1:200-1:1000ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TLK1 |
| Gene ID: | 9874 |
| Uniprot ID: | TLK1_HUMAN |
| Immunogen Region: | 730-779 aa |
| Specificity: | TLK1 Polyclonal Antibody detects endogenous levels of TLK1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TLK1 at the amino acid range 730-779 |
| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
| Protein Name | Serine/Threonine-Protein Kinase Tousled-Like 1Pku-BetaTousled-Like Kinase 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tousled-Like 1 antibodyAnti-Pku-Beta antibodyAnti-Tousled-Like Kinase 1 antibodyAnti-TLK1 antibodyAnti-KIAA0137 antibody |
Information sourced from Uniprot.org