| Short Description : | Rabbit monoclonal Transducin-Like Enhancer Protein 4 (1-138) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5208RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TLE4 |
| Gene ID: | 7091 |
| Uniprot ID: | TLE4_HUMAN |
| Immunogen Region: | 1-138 |
| Immunogen Sequence: | MIRDLSKMYPQTRHPAPHQP AQPFKFTISESCDRIKEEFQ FLQAQYHSLKLECEKLASEK TEMQRHYVMYYEMSYGLNIE MHKQAEIVKRLNAICAQVIP FLSQEHQQQVVQAVERAKQV TMAELNAIIGQQLQAQHL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-138 of human TLE4 (NP_001269677). |
| Tissue Specificity | In all tissues examined, mostly in brain, and muscle. |
| Post Translational Modifications | Phosphorylated. PAX5 binding increases phosphorylation. Ubiquitinated by XIAP/BIRC4. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression. Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU. |
| Protein Name | Transducin-Like Enhancer Protein 4Grg-4Groucho-Related Protein 4 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947Reactome: R-HSA-3769402Reactome: R-HSA-4641265 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 4 antibodyAnti-Grg-4 antibodyAnti-Groucho-Related Protein 4 antibodyAnti-TLE4 antibodyAnti-GRG4 antibodyAnti-KIAA1261 antibody |
Information sourced from Uniprot.org
