| Post Translational Modifications | Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Ubiquitinated at Lys-720 by UBR5 in response to Wnt signaling, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. |
| Protein Name | Transducin-Like Enhancer Protein 3Enhancer Of Split Groucho-Like Protein 3Esg3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-2122947 Q04726-3Reactome: R-HSA-3769402Reactome: R-HSA-4641265Reactome: R-HSA-9018519 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 3 antibodyAnti-Enhancer Of Split Groucho-Like Protein 3 antibodyAnti-Esg3 antibodyAnti-TLE3 antibodyAnti-KIAA1547 antibody |
Information sourced from Uniprot.org
