| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Monkey |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Thymidine kinase, cytosolic (161-210 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TK1 |
| Gene ID: |
7083 |
| Uniprot ID: |
KITH_HUMAN |
| Immunogen Region: |
161-210 aa |
| Specificity: |
Thymidine Kinase Polyclonal Antibody detects endogenous levels of Thymidine Kinase protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human KITH at the amino acid range 161-210 |
| Function | Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT). |
| Protein Name | Thymidine Kinase - Cytosolic |
| Database Links | Reactome: R-HSA-69205Reactome: R-HSA-73614 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Thymidine Kinase - Cytosolic antibodyAnti-TK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
