| Tissue Specificity | This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. |
| Function | Plays a role in tight junctions and adherens junctions. Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity. |
| Protein Name | Tight Junction Protein 2Tight Junction Protein Zo-2Zona Occludens Protein 2Zonula Occludens Protein 2 |
| Database Links | Reactome: R-HSA-2028269Reactome: R-HSA-351906Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | Cell JunctionAdherens JunctionCell MembranePeripheral Membrane ProteinCytoplasmic SideTight JunctionNucleusAlso Nuclear Under Environmental Stress Conditions And In Migratory Endothelial Cells And Subconfluent Epithelial Cell CulturesLocalizes To Tight Junctions During Initial Stages Of Their Formation |
| Alternative Antibody Names | Anti-Tight Junction Protein 2 antibodyAnti-Tight Junction Protein Zo-2 antibodyAnti-Zona Occludens Protein 2 antibodyAnti-Zonula Occludens Protein 2 antibodyAnti-TJP2 antibodyAnti-X104 antibodyAnti-ZO2 antibody |
Information sourced from Uniprot.org
