| Host: |
Rabbit |
| Applications: |
WB/IP |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TJP2 (951-1190) is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IP 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TJP2 |
| Gene ID: |
9414 |
| Uniprot ID: |
ZO2_HUMAN |
| Immunogen Region: |
951-1190 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 951-1190 of human TJP2 (NP_004808.2). |
| Immunogen Sequence: |
RSSEPVQHEESIRKPSPEPR AQMRRAASSDQLRDNSPPPA FKPEPPKAKTQNKEESYDFS KSYEYKSNPSAVAGNETPGA STKGYPPPVAAKPTFGRSIL KPSTPIPPQEGEEVGESSEE QDNAPKSVLGKVKIFEKMDH KARLQRMQELQEAQNARIEI AQKHPDIYAVPIKTHKPDPG TPQHTSSRPPEPQKAPSRPY QDTRGSYGSDAEEEEYRQQL SEHSKRGYYGQSARYRDTE |
| Tissue Specificity | This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues. |
| Function | Plays a role in tight junctions and adherens junctions. Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity. |
| Protein Name | Tight Junction Protein Zo-2Tight Junction Protein 2Zona Occludens Protein 2Zonula Occludens Protein 2 |
| Database Links | Reactome: R-HSA-2028269Reactome: R-HSA-351906Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | Cell JunctionAdherens JunctionCell MembranePeripheral Membrane ProteinCytoplasmic SideTight JunctionNucleusAlso Nuclear Under Environmental Stress Conditions And In Migratory Endothelial Cells And Subconfluent Epithelial Cell Cultures |
| Alternative Antibody Names | Anti-Tight Junction Protein Zo-2 antibodyAnti-Tight Junction Protein 2 antibodyAnti-Zona Occludens Protein 2 antibodyAnti-Zonula Occludens Protein 2 antibodyAnti-TJP2 antibodyAnti-X104 antibodyAnti-ZO2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
