| Host: | Mouse |
| Applications: | IHC-P/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-TIMP-1 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 2A5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Culture supernatant with 0.05% sodium azide |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | TIMP1 |
| Gene ID: | 7076 |
| Uniprot ID: | TIMP1_HUMAN |
| Immunogen: | human TIMP-1 peptide: FQALGDAADIR |
| Tissue Specificity | Detected in rheumatoid synovial fluid (at protein level). |
| Post Translational Modifications | The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated. |
| Function | Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro.but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. |
| Protein Name | Metalloproteinase Inhibitor 1 Erythroid-Potentiating Activity Epa Fibroblast Collagenase Inhibitor Collagenase Inhibitor Tissue Inhibitor Of Metalloproteinases 1 Timp-1 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-1592389 Reactome: R-HSA-381426 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-8957275 Reactome: R-HSA-9839383 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 1 antibody Anti-Erythroid-Potentiating Activity antibody Anti-Epa antibody Anti-Fibroblast Collagenase Inhibitor antibody Anti-Collagenase Inhibitor antibody Anti-Tissue Inhibitor Of Metalloproteinases 1 antibody Anti-Timp-1 antibody Anti-TIMP1 antibody Anti-CLGI antibody Anti-TIMP antibody |
Information sourced from Uniprot.org