| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | TIMM23 |
| Gene ID: | 100287932 |
| Uniprot ID: | TIM23_HUMAN |
| Immunogen Region: | 1-209 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-209 of human TIMM23 (NP_006318.1). |
| Immunogen Sequence: | MEGGGGSGNKTTGGLAGFFG AGGAGYSHADLAGVPLTGMN PLSPYLNVDPRYLVQDTDEF ILPTGANKTRGRFELAFFTI GGCCMTGAAFGAMNGLRLGL KETQNMAWSKPRNVQILNMV TRQGALWANTLGSLALLYSA FGVIIEKTRGAEDDLNTVAA GTMTGMLYKCTGGLRGIARG GLTGLTLTSLYALYNNWEHM KGSLLQQSL |
| Function | Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has a role in the activation of stress-induced mitophagy by protecting PINK1 from OMA1-mediated degradation and facilitating its accumulation at the outer mitochondrial membrane in response to depolarization. |
| Protein Name | Mitochondrial Import Inner Membrane Translocase Subunit Tim23 |
| Database Links | Reactome: R-HSA-1268020 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Import Inner Membrane Translocase Subunit Tim23 antibodyAnti-TIMM23 antibodyAnti-TIM23 antibody |
Information sourced from Uniprot.org