| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Thrombomodulin/CD141 (69-194aa) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ZM105 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a/Kappa |
| Formulation: |
Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Purification: |
Affinity purified |
| Dilution Range: |
1:100‐200 |
| Storage Instruction: |
Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: |
THBD |
| Gene ID: |
7056 |
| Uniprot ID: |
TRBM_HUMAN |
| Immunogen Region: |
69-194aa |
| Specificity: |
Positive control: Mesothelioma |
| Immunogen: |
Recombinant human thrombomodulin protein fragment (aa69-194) |
| Tissue Specificity | Endothelial cells are unique in synthesizing thrombomodulin. |
| Post Translational Modifications | N-glycosylated. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
| Function | Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. |
| Protein Name | ThrombomodulinTmFetomodulinCd Antigen Cd141 |
| Database Links | Reactome: R-HSA-140875Reactome: R-HSA-202733 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Thrombomodulin antibodyAnti-Tm antibodyAnti-Fetomodulin antibodyAnti-Cd Antigen Cd141 antibodyAnti-THBD antibodyAnti-THRM antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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