| Short Description : | Rabbit polyclonal THPO (22-349) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | THPO |
| Gene ID: | 7066 |
| Uniprot ID: | TPO_HUMAN |
| Immunogen Region: | 22-349 |
| Immunogen Sequence: | SPAPPACDLRVLSKLLRDSH VLHSRLSQCPEVHPLPTPVL LPAVDFSLGEWKTQMEETKA QDILGAVTLLLEGVMAARGQ LGPTCLSSLLGQLSGQVRLL LGALQSLLGTQGRTTAHKDP NAIFLSFQHLLRGKVRFLML VGGSTLCVRRAPPTTAVPSR TSLVLTLNELPNRTSGLLET NFTASARTTGSGLLKWQQGF RAKIPGLLNQTSRSLDQIPG YLNRIHELLNGTRGLFPGP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-349 of human THPO (NP_001171068.1). |
| Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Protein Name | ThrombopoietinC-Mpl LigandMlMegakaryocyte Colony-Stimulating FactorMegakaryocyte Growth And Development FactorMgdfMyeloproliferative Leukemia Virus Oncogene Ligand |
| Database Links | Reactome: R-HSA-76009 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Thrombopoietin antibodyAnti-C-Mpl Ligand antibodyAnti-Ml antibodyAnti-Megakaryocyte Colony-Stimulating Factor antibodyAnti-Megakaryocyte Growth And Development Factor antibodyAnti-Mgdf antibodyAnti-Myeloproliferative Leukemia Virus Oncogene Ligand antibodyAnti-THPO antibodyAnti-MGDF antibody |
Information sourced from Uniprot.org
