Anti-THOC6 antibody (50-150) (STJ119802)

Name: Anti-THOC6 antibody (50-150) (STJ119802)
SKU: STJ119802
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ119802

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Short Description	Rabbit polyclonal THOC6 (50-150) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	THOC6
Gene ID	79228
Uniprot ID	THOC6_HUMAN
Immunogen Region	50-150
Immunogen Sequence	IFSLSSALSSEAKEESKKPV VTFQAHDGPVYSMVSTDRHL LSAGDGEVKAWLWAEMLKKG CKELWRRQPPYRTSLEVPEI NALLLVPKENSLILAGGDCQ L
Specificity	A synthetic peptide corresponding to a sequence within amino acids 50-150 of human THOC6 (NP_077315.2).

Function	Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Plays a role in apoptosis negative control involved in brain development. (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Protein Name	Tho Complex Subunit 6 Functional Spliceosome-Associated Protein 35 Fsap35 Wd Repeat-Containing Protein 58
Database Links	Reactome: R-HSA-159236 Reactome: R-HSA-72187 Reactome: R-HSA-73856
Cellular Localisation	Nucleus Nucleus Speckle
Alternative Antibody Names	Anti-Tho Complex Subunit 6 antibody Anti-Functional Spliceosome-Associated Protein 35 antibody Anti-Fsap35 antibody Anti-Wd Repeat-Containing Protein 58 antibody Anti-THOC6 antibody Anti-WDR58 antibody Anti-PSEC0006 antibody

Information sourced from Uniprot.org