Anti-THEMIS antibody (N-Term) (STJA0005614)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThemis (N-terminal region) antibody was generated from a peptide that included amino acids in the N-terminal region of human themis. This sequence has high homology to the conserved region in rat and mouse themis.
General Information
| Short Description | Rabbit polyclonal antibody anti-Themis (N-Term) is suitable for use in Western Blot research applications. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:1000 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | THEMIS |
| Gene ID | 387357 |
| Uniprot ID | THMS1_HUMAN |
| Immunogen | Themis (N-terminal region) antibody was generated from a peptide that included amino acids in the N-terminal region of human themis. This sequence has high homology to the conserved region in rat and mouse themis. |
| Immunogen Region | N-Term |
| Specificity | The antibody detects a 72 kDa* protein corresponding to the molecular mass of themis on SDS-PAGE immunoblots of mouse spleen and human K562 cells. |
Additional Info
| Function | Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. |
| Protein Name | Protein ThemisThymocyte-Expressed Molecule Involved In Selection |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Protein Themis antibodyAnti-Thymocyte-Expressed Molecule Involved In Selection antibodyAnti-THEMIS antibodyAnti-C6orf190 antibodyAnti-C6orf207 antibody |
Information sourced from Uniprot.org