• Hela whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-CD141 (ABT145) antibody. The HRP-conjugated Goat anti- mouse IgG (H + L) antibody was used to detect the antibody. Lane 1: HelaPredicted band size: 60kDaObserved band size: 100kDa
  • THP1 whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-CD141 (ABT145) antibody. The HRP-conjugated Goat anti- mouse IgG (H + L) antibody was used to detect the antibody. Lane 1: THP1Predicted band size: 70kDaObserved band size: 70kDa
  • Human placenta tissue was stained with anti-CD141 (ABT145) antibody.

Anti-THBD antibody (50-150 aa) [ABT145] (STJ197110)

SKU:
STJ197110

£174.00 - £252.00
Current Stock:
Host: Mouse
Applications: IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Thrombomodulin (50-150 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: ABT145
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: IHC-P 1:100-500
WB 1:200-1000
IF 1:100-500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: THBD
Gene ID: 7056
Uniprot ID: TRBM_HUMAN
Immunogen Region: 50-150 aa
Specificity: The antibody can specifically recognize human CD141 protein.
Immunogen: Synthesized peptide derived from the human CD141 at the amino acid range 50-150
Post Translational Modifications N-glycosylated. The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Function Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation. Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.
Protein Name Thrombomodulin
Tm
Fetomodulin
Cd Antigen Cd141
Database Links Reactome: R-HSA-140875
Reactome: R-HSA-202733
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Thrombomodulin antibody
Anti-Tm antibody
Anti-Fetomodulin antibody
Anti-Cd Antigen Cd141 antibody
Anti-THBD antibody
Anti-THRM antibody

Information sourced from Uniprot.org

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