| Function | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. |
| Protein Name | Trimethylguanosine SynthaseCll-Associated Antigen Kw-2Cap-Specific Guanine-N(2 MethyltransferaseHepatocellular Carcinoma-Associated Antigen 137Nuclear Receptor Coactivator 6-Interacting ProteinPrip-Interacting Protein With Methyltransferase MotifPimtPipmt |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-191859Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-381340Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9707564Reactome: R-HSA-9707616 |
| Cellular Localisation | CytoplasmNucleusCajal BodyNucleolusA 90 Kda Isoform Is Found In The Nucleus While A 55 Kda Isoform Is Found In The Cytoplasm And Colocalizes With The Tubulin Network |
| Alternative Antibody Names | Anti-Trimethylguanosine Synthase antibodyAnti-Cll-Associated Antigen Kw-2 antibodyAnti-Cap-Specific Guanine-N(2 Methyltransferase antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 137 antibodyAnti-Nuclear Receptor Coactivator 6-Interacting Protein antibodyAnti-Prip-Interacting Protein With Methyltransferase Motif antibodyAnti-Pimt antibodyAnti-Pipmt antibodyAnti-TGS1 antibodyAnti-HCA137 antibodyAnti-NCOA6IP antibodyAnti-PIMT antibody |
Information sourced from Uniprot.org
