| Short Description : | Rabbit polyclonal TGIF1 (250-340) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TGIF1 |
| Gene ID: | 7050 |
| Uniprot ID: | TGIF1_HUMAN |
| Immunogen Region: | 250-340 |
| Immunogen Sequence: | SSVESVMGIKNFMPALEETP FHSCTAGPNPTLGRPLSPKP SSPGSVLARPSVICHTTVTA LKDVPFSLCQSVGVGQNTDI QQIAAKNFTDT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 250-340 of human TGIF1 (NP_733796.2). |
| Function | Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. |
| Protein Name | Homeobox Protein Tgif15'-Tg-3'-Interacting Factor 1 |
| Database Links | Reactome: R-HSA-2173795Reactome: R-HSA-2173796 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Tgif1 antibodyAnti-5'-Tg-3'-Interacting Factor 1 antibodyAnti-TGIF1 antibodyAnti-TGIF antibody |
Information sourced from Uniprot.org
