Anti-TGFBR3 antibody (Internal) (STJ71525)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TGFBR3 (Internal) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Applications | Pep-ELISA/IF/FC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary testing showed a consistent band at approx 75kDa in MCF7 and K562 cell lysates and in Human Kidney lysates after 1µg/ml antibody staining. This band was successfully blocke |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TGFBR3 |
| Gene ID | 7049 |
| Uniprot ID | TGBR3_HUMAN |
| Accession Number | NP_003234.2; NP_001182613.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | TKSIRDDIPSTQGN |
Additional Info
| Function | Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility. Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization. Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway. (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL. |
| Protein Name | Transforming Growth Factor Beta Receptor Type 3Tgf-Beta Receptor Type 3Tgfr-3BetaglycanTransforming Growth Factor Beta Receptor IiiTgf-Beta Receptor Type Iii |
| Database Links | Reactome: R-HSA-1502540Reactome: R-HSA-190370Reactome: R-HSA-190373Reactome: R-HSA-201451Reactome: R-HSA-2173789Reactome: R-HSA-9839383Reactome: R-HSA-9839389Reactome: R-HSA-9839394Reactome: R-HSA-9839397Reactome: R-HSA-9839406 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExtracellular SpaceExtracellular MatrixExists Both As A Membrane-Bound Form And As Soluble Form In Serum And In The Extracellular Matrix |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Receptor Type 3 antibodyAnti-Tgf-Beta Receptor Type 3 antibodyAnti-Tgfr-3 antibodyAnti-Betaglycan antibodyAnti-Transforming Growth Factor Beta Receptor Iii antibodyAnti-Tgf-Beta Receptor Type Iii antibodyAnti-TGFBR3 antibody |
Information sourced from Uniprot.org