| Post Translational Modifications | Iodinated on tyrosine residues by TPO. There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2573 is coupled to donor Tyr-2540, acceptor Tyr-2766 in monomer 1 is coupled to donor Tyr-2766 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-108 in monomer 2. Sulfated tyrosines are desulfated during iodination. Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones. In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL. Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4. Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones. |
| Function | Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules. |
| Protein Name | ThyroglobulinTg |
| Cellular Localisation | SecretedSecreted Into The Thyroid Follicle LumenLocalizes To Colloid GlobulesA Structure Formed In The Thyroid Follicle Lumen Consisting Of Cross-Linked Tg Arranged In Concentric Layers |
| Alternative Nanobody Names | Anti-Thyroglobulin nanobodyAnti-Tg nanobodyAnti-TG nanobody |
Information sourced from Uniprot.org
![Anti-TG/Thyroglobulin nanobody [SAA1339] (STJN000077)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200690/412872/STJN000077-SDS-PAGE-1__99005.1749232416.jpg?c=1 "Anti-TG/Thyroglobulin nanobody [SAA1339] (STJN000077)")
![Anti-TG/Thyroglobulin nanobody [SAA1339] (STJN000077)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200690/412872/STJN000077-SDS-PAGE-1__99005.1749232416.jpg?c=1 "Anti-TG/Thyroglobulin nanobody [SAA1339] (STJN000077)")
![Anti-TG/Thyroglobulin antibody [SAA0534] (STJA0019368)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/188084/412601/STJA0019368-SDS-PAGE-1__45344.1749229280.jpg?c=1 "Anti-TG/Thyroglobulin antibody [SAA0534] (STJA0019368)")
