| Short Description : | Rabbit polyclonal anti-Transcription factor Dp-1 (361-410 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TFDP1 |
| Gene ID: | 7027 |
| Uniprot ID: | TFDP1_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human DP-1 at the amino acid range 361-410 |
| Immunogen Region: | 361-410 aa |
| Specificity: | TFDP1 Polyclonal Antibody detects endogenous levels of TFDP1 protein. |
| Post Translational Modifications | Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation. Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation. |
| Function | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTCCGCGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters. |
| Protein Name | Transcription Factor Dp-1Drtf1-Polypeptide 1Drtf1E2f Dimerization Partner 1 |
| Database Links | Reactome: R-HSA-111448Reactome: R-HSA-113501Reactome: R-HSA-1362277Reactome: R-HSA-1362300Reactome: R-HSA-139915Reactome: R-HSA-1538133Reactome: R-HSA-1912408Reactome: R-HSA-2173796Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-6804114Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69231Reactome: R-HSA-69656Reactome: R-HSA-8953750Reactome: R-HSA-9616222Reactome: R-HSA-9661069 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Cytoplasm And Nucleus And Translocates Into The Nuclear Compartment Upon Heterodimerization With E2f1 |
| Alternative Antibody Names | Anti-Transcription Factor Dp-1 antibodyAnti-Drtf1-Polypeptide 1 antibodyAnti-Drtf1 antibodyAnti-E2f Dimerization Partner 1 antibodyAnti-TFDP1 antibodyAnti-DP1 antibody |
Information sourced from Uniprot.org
