| Tissue Specificity | Ubiquitously expressed. |
| Function | S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity. |
| Protein Name | Dimethyladenosine Transferase 2 - MitochondrialHepatitis C Virus Ns5a-Transactivated Protein 5Hcv Ns5a-Transactivated Protein 5Mitochondrial 12s Rrna Dimethylase 2Mitochondrial Transcription Factor B2H-MttfbH-Mttfb2Htfb2mMttfb2S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 2 |
| Database Links | Reactome: R-HSA-163282Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Dimethyladenosine Transferase 2 - Mitochondrial antibodyAnti-Hepatitis C Virus Ns5a-Transactivated Protein 5 antibodyAnti-Hcv Ns5a-Transactivated Protein 5 antibodyAnti-Mitochondrial 12s Rrna Dimethylase 2 antibodyAnti-Mitochondrial Transcription Factor B2 antibodyAnti-H-Mttfb antibodyAnti-H-Mttfb2 antibodyAnti-Htfb2m antibodyAnti-Mttfb2 antibodyAnti-S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 2 antibodyAnti-TFB2M antibodyAnti-NS5ATP5 antibody |
Information sourced from Uniprot.org
