Anti-TFB2M antibody (192-242 aa) (STJ195420)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TFB2M at the amino acid range 192-242
General Information
| Short Description | Rabbit polyclonal anti-Dimethyladenosine transferase 2, mitochondrial dimethyltransferase 2 (192-242 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TFB2M |
| Gene ID | 64216 |
| Uniprot ID | TFB2M_HUMAN |
| Immunogen | Synthesized peptide derived from the human TFB2M at the amino acid range 192-242 |
| Immunogen Region | 192-242 aa |
| Specificity | This antibody detects endogenous levels of TFB2M at Human/Mouse/Rat |
Additional Info
| Function | S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (Probable). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Stimulates transcription independently of the methyltransferase activity. |
| Protein Name | Dimethyladenosine Transferase 2 - MitochondrialHepatitis C Virus Ns5a-Transactivated Protein 5Hcv Ns5a-Transactivated Protein 5Mitochondrial 12s Rrna Dimethylase 2Mitochondrial Transcription Factor B2H-MttfbH-Mttfb2Htfb2mMttfb2S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 2 |
| Database Links | Reactome: R-HSA-163282Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Dimethyladenosine Transferase 2 - Mitochondrial antibodyAnti-Hepatitis C Virus Ns5a-Transactivated Protein 5 antibodyAnti-Hcv Ns5a-Transactivated Protein 5 antibodyAnti-Mitochondrial 12s Rrna Dimethylase 2 antibodyAnti-Mitochondrial Transcription Factor B2 antibodyAnti-H-Mttfb antibodyAnti-H-Mttfb2 antibodyAnti-Htfb2m antibodyAnti-Mttfb2 antibodyAnti-S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 2 antibodyAnti-TFB2M antibodyAnti-NS5ATP5 antibody |
Information sourced from Uniprot.org