Anti-TFB1M antibody (C-Term) (STJ71996)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TFB1M (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 38kDa band observed in lysates of cell line A431 (calculated MW of 39.5kDa according to NP_057104.2). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TFB1M |
| Gene ID | 51106 |
| Uniprot ID | TFB1M_HUMAN |
| Accession Number | NP_057104.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | ELKRRKSKNEEKE |
Additional Info
| Function | Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. |
| Protein Name | Dimethyladenosine Transferase 1 - MitochondrialMitochondrial 12s Rrna Dimethylase 1Mitochondrial Transcription Factor B1H-MttfbH-Mttfb1Htfb1mMttfb1S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-6793080 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Dimethyladenosine Transferase 1 - Mitochondrial antibodyAnti-Mitochondrial 12s Rrna Dimethylase 1 antibodyAnti-Mitochondrial Transcription Factor B1 antibodyAnti-H-Mttfb antibodyAnti-H-Mttfb1 antibodyAnti-Htfb1m antibodyAnti-Mttfb1 antibodyAnti-S-Adenosylmethionine-6-N' - N'-Adenosyl(Rrna Dimethyltransferase 1 antibodyAnti-TFB1M antibodyAnti-CGI-75 antibody |
Information sourced from Uniprot.org