Anti-TFAP2B antibody (18-68 aa) (STJ194241)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human AP2B at the amino acid range 18-68
General Information
| Short Description | Rabbit polyclonal anti-Transcription factor AP-2-beta (18-68 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TFAP2B |
| Gene ID | 7021 |
| Uniprot ID | AP2B_HUMAN |
| Immunogen | Synthesized peptide derived from the human AP2B at the amino acid range 18-68 |
| Immunogen Region | 18-68 aa |
| Specificity | This antibody detects endogenous levels of AP2B at Human/Mouse |
Additional Info
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. |
| Protein Name | Transcription Factor Ap-2-BetaAp2-BetaActivating Enhancer-Binding Protein 2-Beta |
| Database Links | Reactome: R-HSA-3232118Reactome: R-HSA-8866904Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-9834899 |
| Cellular Localisation | NucleusIn The BrainLocalizes To The Arcuate Hypothalamic NucleusThe Ventromedial Hypothalamic Nucleus And The Accumbens Nucleus Of The Ventral Striatum |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2-Beta antibodyAnti-Ap2-Beta antibodyAnti-Activating Enhancer-Binding Protein 2-Beta antibodyAnti-TFAP2B antibody |
Information sourced from Uniprot.org