| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Transcription factor AP-2-beta (18-68 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TFAP2B |
| Gene ID: | 7021 |
| Uniprot ID: | AP2B_HUMAN |
| Immunogen Region: | 18-68 aa |
| Specificity: | This antibody detects endogenous levels of AP2B at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human AP2B at the amino acid range 18-68 |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. |
| Protein Name | Transcription Factor Ap-2-BetaAp2-BetaActivating Enhancer-Binding Protein 2-Beta |
| Database Links | Reactome: R-HSA-3232118Reactome: R-HSA-8866904Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-9834899 |
| Cellular Localisation | NucleusIn The BrainLocalizes To The Arcuate Hypothalamic NucleusThe Ventromedial Hypothalamic Nucleus And The Accumbens Nucleus Of The Ventral Striatum |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2-Beta antibodyAnti-Ap2-Beta antibodyAnti-Activating Enhancer-Binding Protein 2-Beta antibodyAnti-TFAP2B antibody |
Information sourced from Uniprot.org
