Anti-TFAP2A antibody (120-200) (STJ110952)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TFAP2A (120-200) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TFAP2A |
| Gene ID | 7020 |
| Uniprot ID | AP2A_HUMAN |
| Immunogen Region | 120-200 |
| Immunogen Sequence | GLDPRRDYRRHEDLLHGPHA LSSGLGDLSIHSLPHAIEEV PHVEDPGINIPDQTVIKKGP VSLSKSNSNAVSAIPINKDN L |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 120-200 of human Activator protein 2 (AP-2/TFAP2A) (NP_003211.1). |
Additional Info
| Post Translational Modifications | Sumoylated on Lys-10.which inhibits transcriptional activity. |
| Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. |
| Protein Name | Transcription Factor Ap-2-AlphaAp2-AlphaAp-2 Transcription FactorActivating Enhancer-Binding Protein 2-AlphaActivator Protein 2Ap-2 |
| Database Links | Reactome: R-HSA-3232118 P05549-1Reactome: R-HSA-8864260Reactome: R-HSA-8866904Reactome: R-HSA-8866906Reactome: R-HSA-8866907Reactome: R-HSA-8866910Reactome: R-HSA-8866911Reactome: R-HSA-8869496Reactome: R-HSA-9824585Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Ap-2-Alpha antibodyAnti-Ap2-Alpha antibodyAnti-Ap-2 Transcription Factor antibodyAnti-Activating Enhancer-Binding Protein 2-Alpha antibodyAnti-Activator Protein 2 antibodyAnti-Ap-2 antibodyAnti-TFAP2A antibodyAnti-AP2TF antibodyAnti-TFAP2 antibody |
Information sourced from Uniprot.org