Anti-TEX15 antibody (STJA0007629)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TEX15
General Information
| Short Description | Rabbit polyclonal anti-Testis-expressed protein 15 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TEX15Uniprot ID=TEX15_HUMAN" |
| Immunogen | Synthesized peptide derived from human TEX15 |
| Specificity | This antibody detects endogenous levels of TEX15 at Human |
Additional Info
| Function | Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair. Essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells. PIWIL4-piRNA binds to nascent transposon transcripts and interacts with TEX15, which may in turn recruit the epigenetic silencing machinery to the transposon loci. Not required for piRNA biosynthesis. |
| Protein Name | Testis-Expressed Protein 15Cancer/Testis Antigen 42Ct42 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Testis-Expressed Protein 15 antibodyAnti-Cancer/Testis Antigen 42 antibodyAnti-Ct42 antibodyAnti-TEX15 antibody |
Information sourced from Uniprot.org