| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Dual specificity testis-specific protein kinase 1 (181-230 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TESK1 |
| Gene ID: |
7016 |
| Uniprot ID: |
TESK1_HUMAN |
| Immunogen Region: |
181-230 aa |
| Specificity: |
TESK1 Polyclonal Antibody detects endogenous levels of TESK1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human TESK1 at the amino acid range 181-230 |
| Post Translational Modifications | Autophosphorylated on serine and tyrosine residues. |
| Function | Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1. Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin. Suppresses ciliogenesis via multiple pathways.phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. Probably plays a central role at and after the meiotic phase of spermatogenesis. |
| Protein Name | Dual Specificity Testis-Specific Protein Kinase 1Testicular Protein Kinase 1 |
| Database Links | Reactome: R-HSA-446388 |
| Cellular Localisation | CytoplasmPerinuclear RegionCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionLamellipodiumColocalizes With Spry4 In Vesicular Spots In The CytoplasmLocalized To F-Actin-Rich Lamellipodia At The Cell Periphery Following Fibronectin-Mediated Cell Adhesion Of Schwann Cells |
| Alternative Antibody Names | Anti-Dual Specificity Testis-Specific Protein Kinase 1 antibodyAnti-Testicular Protein Kinase 1 antibodyAnti-TESK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
