Anti-TESC antibody (20-70 aa) (STJ195252)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CHP3 at the amino acid range 20-70
General Information
| Short Description | Rabbit polyclonal anti-Calcineurin B homologous protein 3 (20-70 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TESC |
| Gene ID | 54997 |
| Uniprot ID | CHP3_HUMAN |
| Immunogen | Synthesized peptide derived from the human CHP3 at the amino acid range 20-70 |
| Immunogen Region | 20-70 aa |
| Specificity | This antibody detects endogenous levels of CHP3 at Human/Mouse |
Additional Info
| Function | Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. |
| Protein Name | Calcineurin B Homologous Protein 3TescalcinTsc |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmMembraneLipid-AnchorCell MembraneCell ProjectionLamellipodiumRuffle MembraneColocalizes With Slc9a1 At The Plasma Membrane |
| Alternative Antibody Names | Anti-Calcineurin B Homologous Protein 3 antibodyAnti-Tescalcin antibodyAnti-Tsc antibodyAnti-TESC antibodyAnti-CHP3 antibody |
Information sourced from Uniprot.org