| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Telomere length regulation protein TEL2 homolog (605-655) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TELO2 |
| Gene ID: |
9894 |
| Uniprot ID: |
TELO2_HUMAN |
| Immunogen Region: |
605-655 |
| Specificity: |
This antibody detects endogenous levels of human TELO2 |
| Immunogen: |
Synthesized peptide derived from human TELO2 AA range: 605-655 |
| Function | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation. |
| Protein Name | Telomere Length Regulation Protein Tel2 HomologProtein Clk-2 HomologHclk2 |
| Cellular Localisation | CytoplasmMembraneNucleusChromosomeTelomere |
| Alternative Antibody Names | Anti-Telomere Length Regulation Protein Tel2 Homolog antibodyAnti-Protein Clk-2 Homolog antibodyAnti-Hclk2 antibodyAnti-TELO2 antibodyAnti-KIAA0683 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
