Anti-TEB4/MARCH-VI antibody (701-712) (STJ71436)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TEB4/MARCH-VI (701-712) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 100kDa band observed in Human Lung lysates (calculated MW of 103kDa according to NP_005876.2). Recommended concentration: 0.2-0.5ยตg/ml. An additional band of unknown identity wa |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | MARCHF6 |
| Gene ID | 10299 |
| Uniprot ID | MARH6_HUMAN |
| Accession Number | NP_005876.2 |
| Immunogen Region | 701-712 |
| Immunogen Sequence | QGRRVIFQKVKE |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated, which results in proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Marchf6Doa10 HomologMembrane-Associated Ring Finger Protein 6Membrane-Associated Ring-Ch Protein ViMarch-ViProtein Teb-4Ring Finger Protein 176Ring-Type E3 Ubiquitin Transferase Marchf6 |
| Database Links | Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Marchf6 antibodyAnti-Doa10 Homolog antibodyAnti-Membrane-Associated Ring Finger Protein 6 antibodyAnti-Membrane-Associated Ring-Ch Protein Vi antibodyAnti-March-Vi antibodyAnti-Protein Teb-4 antibodyAnti-Ring Finger Protein 176 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Marchf6 antibodyAnti-MARCHF6 antibodyAnti-KIAA0597 antibodyAnti-MARCH6 antibodyAnti-RNF176 antibodyAnti-TEB4 antibody |
Information sourced from Uniprot.org