| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. |
| Protein Name | Transcriptional Enhancer Factor Tef-4Tea Domain Family Member 2Tead-2 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8951671Reactome: R-HSA-9796292 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Enhancer Factor Tef-4 antibodyAnti-Tea Domain Family Member 2 antibodyAnti-Tead-2 antibodyAnti-TEAD2 antibodyAnti-TEF4 antibody |
Information sourced from Uniprot.org
