| Post Translational Modifications | Phosphorylated on serine and/or threonine residues, but not on tyrosine residues. |
| Function | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. |
| Protein Name | Tyrosyl-Dna Phosphodiesterase 1Tyr-Dna Phosphodiesterase 1 |
| Database Links | Reactome: R-HSA-5693571 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Tyrosyl-Dna Phosphodiesterase 1 antibodyAnti-Tyr-Dna Phosphodiesterase 1 antibodyAnti-TDP1 antibody |
Information sourced from Uniprot.org
