| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tyrosyl-DNA phosphodiesterase 1 (426-476 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TDP1 |
| Gene ID: |
55775 |
| Uniprot ID: |
TYDP1_HUMAN |
| Immunogen Region: |
426-476 aa |
| Specificity: |
This antibody detects endogenous levels of TYDP1 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human TYDP1 at the amino acid range 426-476 |
| Post Translational Modifications | Phosphorylated on serine and/or threonine residues, but not on tyrosine residues. |
| Function | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. |
| Protein Name | Tyrosyl-Dna Phosphodiesterase 1Tyr-Dna Phosphodiesterase 1 |
| Database Links | Reactome: R-HSA-5693571 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Tyrosyl-Dna Phosphodiesterase 1 antibodyAnti-Tyr-Dna Phosphodiesterase 1 antibodyAnti-TDP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
