| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TCTN1 (130-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TCTN1 |
| Gene ID: |
79600 |
| Uniprot ID: |
TECT1_HUMAN |
| Immunogen Region: |
130-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 130-310 of human TCTN1 (NP_001076006.1). |
| Immunogen Sequence: |
NFTANPPQRVFELVDQINPS IFCIHITNYKPALSFINPEV PDENNFDTLMKTSDGFTLNA ESYVSFTTKLDIPTAAKYEY GVPLQTSDSFLRFPSSLTSS LCTDNNPAAFLVNQAVKCTR KINLEQCEEIEALSMAFYSS PEILRVPDSRKKVPITVQSI VIQSLNKTLTRREDTDVLQP T |
| Function | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23. |
| Protein Name | Tectonic-1 |
| Database Links | Reactome: R-HSA-5620912 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodySecretedDespite The Presence Of A Signal SequenceThe Full-Length Protein Might Not Be SecretedLocalizes At The Transition ZoneA Region Between The Basal Body And The Ciliary Axoneme |
| Alternative Antibody Names | Anti-Tectonic-1 antibodyAnti-TCTN1 antibodyAnti-TECT1 antibodyAnti-UNQ9369 antibodyAnti-PRO34160 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
