| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
TCOF1 |
| Gene ID: |
6949 |
| Uniprot ID: |
TCOF_HUMAN |
| Immunogen Region: |
659-958 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 659-958 of human TCOF1 (NP_001008657.1). |
| Immunogen Sequence: |
VRVGTQAPRKAGTATSPAGS SPAVAGGTQRPAEDSSSSEE SDSEEEKTGLAVTVGQAKSV GKGLQVKAASVPVKGSLGQG TAPVLPGKTGPTVTQVKAEK QEDSESSEEESDSEEAAASP AQVKTSVKKTQAKANPAAAR APSAKGTISAPGKVVTAAAQ AKQRSPSKVKPPVRNPQNST VLARGPASVPSVGKAVATAA QAQTGPEEDSGSSEEESDSE EEAETLAQVKPSGKTHQIR |
| Post Translational Modifications | Ubiquitinated. Monoubiquitination by the BCR(KBTBD8) complex promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. Pyrophosphorylated by 5-diphosphoinositol pentakisphosphate (5-IP7). Serine pyrophosphorylation is achieved by Mg(2+)-dependent, but enzyme independent transfer of a beta-phosphate from a inositol pyrophosphate to a pre-phosphorylated serine residue. |
| Function | Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. |
| Protein Name | Treacle ProteinTreacher Collins Syndrome Protein |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Treacle Protein antibodyAnti-Treacher Collins Syndrome Protein antibodyAnti-TCOF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
