| Function | Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown. In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling. |
| Protein Name | Transcriptional And Immune Response RegulatorThyroid Cancer Protein 1Tc-1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleus SpeckleLocalizes In Nucleus Speckles In Presence Of Cby1Translocates To The Nucleus Upon Cellular Stress Such As H(2)O(2) |
| Alternative Antibody Names | Anti-Transcriptional And Immune Response Regulator antibodyAnti-Thyroid Cancer Protein 1 antibodyAnti-Tc-1 antibodyAnti-TCIM antibodyAnti-C8orf4 antibodyAnti-TC1 antibody |
Information sourced from Uniprot.org
