Anti-TCHH antibody (100-300) (STJ118177)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TCHH (100-300) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TCHH |
| Gene ID | 7062 |
| Uniprot ID | TRHY_HUMAN |
| Immunogen Region | 100-300 |
| Immunogen Sequence | RARCDGKESLLQDRRQEEDQ RRFEPRDRQLEEEPGQRRRQ KRQEQERELAEGEEQSEKQE RLEQRDRQRRDEELWRQRQE WQEREERRAEEEQLQSCKGH ETEEFPDEEQLRRRELLELR RKGREEKQQQRRERQDRVFQ EEEEKEWRKRETVLRKEEEK LQEEEPQRQRELQEEEEQLR KLERQELRRERQEEEQQQQR L |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 100-300 of human TCHH (NP_009044.2). |
Additional Info
| Tissue Specificity | Found in the hard keratinizing tissues such as the inner root sheath (IRS) of hair follicles and medulla, and in the filiform papillae of dorsal tongue epithelium. |
| Post Translational Modifications | Substrate of transglutaminase. Some 200 arginines are probably converted to citrullines by peptidylarginine deimidase. |
| Function | Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. |
| Protein Name | Trichohyalin |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Trichohyalin antibodyAnti-TCHH antibodyAnti-THH antibodyAnti-THL antibodyAnti-TRHY antibody |
Information sourced from Uniprot.org