Anti-TCF7L1 antibody (321-370 aa) (STJ95943)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TCF7L1 at the amino acid range 321-370
General Information
| Short Description | Rabbit polyclonal anti-Transcription factor 7-like 1 (321-370 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TCF7L1 |
| Gene ID | 83439 |
| Uniprot ID | TF7L1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TCF7L1 at the amino acid range 321-370 |
| Immunogen Region | 321-370 aa |
| Specificity | TCF-3 Polyclonal Antibody detects endogenous levels of TCF-3 protein. |
Additional Info
| Function | Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance. |
| Protein Name | Transcription Factor 7-Like 1Hmg Box Transcription Factor 3Tcf-3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3769402Reactome: R-HSA-4086398Reactome: R-HSA-4411364Reactome: R-HSA-4641265Reactome: R-HSA-8951430Reactome: R-HSA-9825892Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor 7-Like 1 antibodyAnti-Hmg Box Transcription Factor 3 antibodyAnti-Tcf-3 antibodyAnti-TCF7L1 antibodyAnti-TCF3 antibody |
Information sourced from Uniprot.org