| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Transcription factor 7 (10-59 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TCF7 |
| Gene ID: | 6932 |
| Uniprot ID: | TCF7_HUMAN |
| Immunogen Region: | 10-59 aa |
| Specificity: | TCF-1 Polyclonal Antibody detects endogenous levels of TCF-1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TCF7 at the amino acid range 10-59 |
| Function | Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages. Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. |
| Protein Name | Transcription Factor 7Tcf-7T-Cell-Specific Transcription Factor 1T-Cell Factor 1Tcf-1 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3769402Reactome: R-HSA-4086398Reactome: R-HSA-4411364Reactome: R-HSA-4641265Reactome: R-HSA-8951430Reactome: R-HSA-9754189Reactome: R-HSA-9796292Reactome: R-HSA-9825892 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor 7 antibodyAnti-Tcf-7 antibodyAnti-T-Cell-Specific Transcription Factor 1 antibodyAnti-T-Cell Factor 1 antibodyAnti-Tcf-1 antibodyAnti-TCF7 antibodyAnti-TCF1 antibody |
Information sourced from Uniprot.org