| Post Translational Modifications | Phosphorylated following NGF stimulation. Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes. |
| Function | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. Isoform E47: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. |
| Protein Name | Transcription Factor E2-AlphaClass B Basic Helix-Loop-Helix Protein 21Bhlhb21Immunoglobulin Enhancer-Binding Factor E12/E47Immunoglobulin Transcription Factor 1Kappa-E2-Binding FactorTranscription Factor 3Tcf-3Transcription Factor Itf-1 |
| Database Links | Reactome: R-HSA-525793Reactome: R-HSA-8939236Reactome: R-HSA-9839394 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor E2-Alpha antibodyAnti-Class B Basic Helix-Loop-Helix Protein 21 antibodyAnti-Bhlhb21 antibodyAnti-Immunoglobulin Enhancer-Binding Factor E12/E47 antibodyAnti-Immunoglobulin Transcription Factor 1 antibodyAnti-Kappa-E2-Binding Factor antibodyAnti-Transcription Factor 3 antibodyAnti-Tcf-3 antibodyAnti-Transcription Factor Itf-1 antibodyAnti-TCF3 antibodyAnti-BHLHB21 antibodyAnti-E2A antibodyAnti-ITF1 antibody |
Information sourced from Uniprot.org
