| Tissue Specificity | Highly expressed in normal and fetal brain tissues, and weakly expressed in uterus and ovary. Down-regulated in epithelial ovarian, cervical, prostate, breast, brain and lung cancer cell lines and in brain and ovarian tumors. |
| Function | Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its target gene promoters. Associates with cyclin D1 promoter containing Myc E-box sequence and transcriptionally represses cyclin D1 expression. Regulates telomerase reverse transcriptase expression and telomerase activity in both ALT (alternative lengthening of telomeres)and telomerase-positive cell lines. |
| Protein Name | Transcription Elongation Factor A Protein-Like 7Tcea-Like Protein 7Transcription Elongation Factor S-Ii Protein-Like 7 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Elongation Factor A Protein-Like 7 antibodyAnti-Tcea-Like Protein 7 antibodyAnti-Transcription Elongation Factor S-Ii Protein-Like 7 antibodyAnti-TCEAL7 antibody |
Information sourced from Uniprot.org
