| Host: | Mouse |
| Applications: | WB/IHC-P/ICC/IF |
| Reactivity: | Human/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-TBLR1 for use in WB, IHC-P, ICC and IF in Human and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Purification: | Affinity Purified |
| Concentration: | 5.8 mg/mL |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | TBL1XR1 |
| Gene ID: | 79718 |
| Uniprot ID: | TBL1R_HUMAN |
| Immunogen: | A synthesized peptide derived from Human TBL1XR1 |
| Tissue Specificity | Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver. |
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. |
| Protein Name | F-Box-Like/Wd Repeat-Containing Protein Tbl1xr1Nuclear Receptor Corepressor/Hdac3 Complex Subunit Tblr1Tbl1-Related Protein 1Transducin Beta-Like 1x-Related Protein 1 |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-1989781Reactome: R-HSA-2122947Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054Reactome: R-HSA-381340Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9022537Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9609690Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9841922 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-F-Box-Like/Wd Repeat-Containing Protein Tbl1xr1 antibodyAnti-Nuclear Receptor Corepressor/Hdac3 Complex Subunit Tblr1 antibodyAnti-Tbl1-Related Protein 1 antibodyAnti-Transducin Beta-Like 1x-Related Protein 1 antibodyAnti-TBL1XR1 antibodyAnti-IRA1 antibodyAnti-TBLR1 antibody |
Information sourced from Uniprot.org
